- Introduction: What are stem cells, and why are they important?
- What are the unique properties of all stem cells?
- What are embryonic stem cells?
- What are adult stem cells?
- What are the similarities and differences between embryonic and adult stem cells?
- What are induced pluripotent stem cells?
- What are the potential uses of human stem cells and the obstacles that must be overcome before these potential uses will be realized?
- Where can I get more information?
PRP & Knee Meniscus News
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Treatment of Knee Meniscus Pathology: Rehabilitation, Surgery, and Orthobiologics.
Chirichella PS1, Jow S2, Iacono S3, Wey HE3, Malanga GA4.
The meniscal tear treatment paradigm traditionally begins with conservative measures such as physical therapy with referral for operative management for persistent or mechanical symptoms. As a result, the partial meniscectomy is performed more than any other orthopedic procedure in the United States. This treatment paradigm has shifted as recent literature supports the attempt to preserve or repair the meniscus whenever possible given its importance for the structural integrity of the knee joint and the risk of early osteoarthritis associated after meniscus excision. Choosing an appropriate management strategy depends on multiple factors such as patient demographics and location of the tear. Physical therapy remains a first line treatment for knee pain secondary to meniscus tear and should be pursued in the setting of both acute and chronic knee pain. Furthermore, there is a growing amount of evidence showing that elderly patients with complex meniscus tears in the setting of degenerative arthritis should not undergo arthroscopic surgery. Direct meniscus repair remains an option in ideal patients who are young, healthy, and have tears near the more vascular periphery of the meniscus but are not suitable for all patients. Use of orthobiologics such as platelet rich plasma and mesenchymal stem cells show promise in augmenting surgical repairs or as stand-alone treatments though research for use in meniscal tear management is limited.Source: Click Here https://www.ncbi.nlm.nih.gov/pubmed/30195704
What is the Role of Platelets in Healing?
This is an article from: Sports Medicine.
Update on platelet-rich plasma by: Jeffrey M. DeLong, Knut Beitzel, Augustus D. Mazzocca, David Shepard, Brandon L. Roller and Bryan T. Hanypsiak
The healing process can be divided into three phases.
Phase 1 (hemostasis and inﬂammation) is triggered by tissue injury and lasts for 2–5 days. During phase 1, platelets become activated when they encounter injured tissue and adhere to the exposed collagen, aggregating to form a clot. 14,15 Degranulation of platelets occurs and the release of growth, bioactive, and hemostatic factors results in inﬂammation. Platelets release 70–95% of the stored growth factors in the ﬁrst 10 minutes after tissue injury and additional growth factors continue to be secreted for 7–9 days. 9,16