Treatment of Knee Joint Osteoarthritis with Autologous Platelet-Rich Plasma in Comparison with Hyaluronic Acid



This study aimed to find a simple, cost-effective, and time-efficient method for the preparation of platelet-rich plasma (PRP), so the acquired benefits will be readily available for multiple procedures in smaller outpatient clinics and to explore the safety and efficacy of the application of PRP in the treatment of degenerative lesions of articular cartilage of the knee.

What is Arthritis?

*Always Remember: Physical Activity can reduce pain and improve physical function by about 40%

Arthritis is very common but not well understood. Actually, “arthritis” is not a single disease; it is an informal way of referring to joint pain or joint disease. There are more than 100 different types of arthritis (see Appendix) and related conditions. People of all ages, genders and races have arthritis, the leading cause of disability in the United States. We don’t know the true number of people with arthritis because many people don’t seek treatment until their symptoms become severe. Conservative estimates only include those who report they have doctor diagnosed arthritis, indicating that about 54 million adults and almost 300,000 children “officially” have arthritis or another type of rheumatic disease. A recent study says as many as 91 million Americans may really have arthritis – when you add together those who are officially diagnosed plus those who report obvious symptoms but haven’t been diagnosed.

While researchers try to find more accurate ways to estimate the prevalence of this disease and the burdens it causes, we do know that it is more common among women and that the number of people of all ages with arthritis is increasing.

Stem Cell Basics

Stem cells are cells with the potential to develop into many different types of cells in the body. They serve as a repair system for the body. There are two main types of stem cells: embryonic stem cells and adult stem cells.

Stem cells are different from other cells in the body in three ways:

-They can divide and renew themselves over a long time
-They are unspecialized, so they cannot do specific functions in the body
-They have the potential to become specialized cells, such as muscle cells, blood cells, and brain cells

Doctors and scientists are excited about stem cells because they could help in many different areas of health and medical research. Studying stem cells may help explain how serious conditions such as birth defects and cancer come about. Stem cells may one day be used to make cells and tissues for therapy of many diseases. Examples include Parkinson’s disease, Alzheimer’s disease, spinal cord injury, heart disease, diabetes, and arthritis.

Source – NIH: National Institutes of Health
Read More Here



The Article Accepted and Published by The US National Library of Medicine, featured in International Orthopaedics on July 10, 2015; “Treatment of discogenic back pain with autologous bone marrow concentrate injection with minimum two year follow-up.” Show there were no complications from the percutaneous bone marrow aspiration or disc injection. Of 26 patients, 24 (92 %) avoided surgery through 12 months, while 21 (81 %) avoided surgery through two years. Total and rate of pain reduction were linked to mesenchymal stem cell concentration through 12 months. Only five of the 26 patients elected to undergo surgical intervention (fusion or artificial disc replacement) by the two year milestone. in conclusion, this study provides evidence of safety and feasibility in the non-surgical treatment of discogenic pain with autologous BMC, with durable pain relief (71 % VAS reduction) and ODI improvements (> 64 %) through two years. Read the Complete Article Here
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